Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients -: art. no. 11

被引：44

作者：

Clarimon, J

Xiromerisiou, G

Eerola, J

Gourbali, V

Hellström, O

Dardiotis, E

Peuralinna, T

Papadimitriou, A

Hadjigeorgiou, GM

Tienari, PJ

Singleton, AB

机构：

[1] NIA, Mol Genet Unit, Neurogenet Lab, NIH, Bethesda, MD 20892 USA

[2] Univ Thessaly, Sch Med, Dept Neurol, Neurogenet Unit, Larisa, Greece

[3] Univ Helsinki, Cent Hosp, Dept Neurol, FIN-00014 Helsinki, Finland

[4] Univ Helsinki, Biomedicum, Neurosci Programme, FIN-00014 Helsinki, Finland

来源：

BMC NEUROLOGY | 2005年 / 5卷 / 1期

关键词：

D O I：

10.1186/1471-2377-5-11

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Fibroblast growth factor 20 (FGF20) is a neurotrophic factor preferentially expressed in the substantia nigra of rat brain and could be involved in dopaminergic neurons survival. Recently, a strong genetic association has been found between FGF20 gene and the risk of suffering from Parkinson's disease (PD). Our aim was to replicate this association in two independent populations. Methods: Allelic, genotypic, and haplotype frequencies of four biallelic polymorphisms were assessed in 151 sporadic PD cases and 186 controls from Greece, and 144 sporadic PD patients and 135 controls from Finland. Results: No association was found in any of the populations studied. Conclusion: Taken together, these findings suggest that common genetic variants in FGF20 are not a risk factor for PD in, at least, some European populations.

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