γ-2 Herpes virus post-transcriptional gene regulation

被引：23

作者：

Boyne, JR

Whitehouse, A ^{[1
]}

机构：

[1] Univ Leeds, Fac Biol Sci, Inst Mol & Cellular Biol, Leeds LS2 9JT, W Yorkshire, England

[2] Univ Leeds, Astbury Ctr Struct Mol Biol, Leeds LS2 9JT, W Yorkshire, England

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2006年 / 12卷 / 02期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

gamma-herpes viruses; herpes virus saimiri; mRNA export; ORF; 57; post-transcriptional modification; review;

D O I：

10.1111/j.1469-0691.2005.01317.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

gamma-2 herpes viruses, which include Kaposi's sarcoma-associated herpes virus, are an important subfamily of herpes virus because of their oncogenic potential. Herpes virus saimiri (HVS) is the prototype gamma-2 herpes virus and is a useful model to study the basic mechanisms of lytic replication in this subfamily. Like all herpes viruses, HVS has two distinct life cycles, latent persistence and lytic replication. Analysis of herpes virus genomes has demonstrated that, in contrast to cellular genes, most virus genes that are expressed lytically do not have introns. Herpes viruses replicate in the nucleus of the host cell, and therefore require that the viral intron-lacking mRNAs are exported from the nucleus to allow virus mRNA translation. This review focuses upon the role of HVS ORF 57, a post-transcriptional regulatory protein, which is conserved in all herpes viruses. HVS ORF 57 is a multifunctional protein involved in both trans-activation and trans-repression of target mRNAs. The major role of the ORF 57 protein in mediating viral mRNA export is considered, and the ORF 57-host cell interactions that are required for this function are discussed.

引用

页码：110 / 117

页数：8

共 37 条

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