The regulation of antigen-receptor signaling by protein tyrosine phosphatases: a hole in the story

被引：54

作者：

Thomas, ML ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Pathol, Howard Hughes Med Inst, St Louis, MO 63110 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1999年 / 11卷 / 03期

关键词：

D O I：

10.1016/S0952-7915(99)80044-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antigen-receptor :signaling requires Src-family kinases to initiate tyrosine phosphorylation.CD45 dephosphorylates the inhibitory site in Src-family kinases before antigen-receptor engagement and thus serves to 'prime' the kinases. It has been unclear why CD45 does not also dephosphorylate 'activated' kinases or motifs within the cytoplasmic domains of antigen- receptors and thus prevent signal transduction. Recent reports raise the possibility that CD45 is excluded from engaged antigen-receptors by mechanisms that may include the formation of lipid microdomains.

引用

页码：270 / 276

页数：7

共 59 条

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