Synthesis and cytotoxicity of analogues of the antibiotic BE 10988 inhibitors of DNA topoisomerase II

被引：13

作者：

Catrycke, MO

Houssin, R

Hénichart, JP

Pfeiffer, B

Renard, P

Dassonneville, L

Bailly, C

机构：

[1] Ctr Oscar Lambret, Lab Pharmacol Antitumorale, F-59045 Lille, France

[2] INSERM, U524, IRCL, F-59045 Lille, France

[3] Univ Lille 2, Inst Chim Pharmaceut, F-59006 Lille, France

[4] ADIR, F-92415 Courbevoie, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(99)00307-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Indolequinone derivatives of the antitumour antibiotic BE 10988 were synthesized and evaluated for their cytotoxicity and action mechanism. The quinone system is essential to biological activity and the thiazole ring plays a major role in the poisoning of topoisomerase II. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：2025 / 2030

页数：6

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