Chronic adipose tissue inflammation: all immune cells on the stage

被引:295
作者
Cildir, Goekhan [1 ,2 ]
Akincilar, Semih Can [1 ,2 ]
Tergaonkar, Vinay [1 ,2 ]
机构
[1] Inst Mol & Cell Biol, Lab NF KB Signaling, Singapore 138673, Singapore
[2] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore 117597, Singapore
关键词
INDUCED INSULIN-RESISTANCE; DIET-INDUCED OBESITY; NECROSIS-FACTOR-ALPHA; NF-KAPPA-B; ALTERNATIVELY ACTIVATED MACROPHAGES; HIGH-FAT DIET; TYPE-2; DIABETES-MELLITUS; REGULATES ENERGY-BALANCE; INVARIANT NKT CELLS; KILLER T-CELLS;
D O I
10.1016/j.molmed.2013.05.001
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
070307 [化学生物学]; 071010 [生物化学与分子生物学];
摘要
Inflammation is indispensable for host homeostasis against invading pathogens and efficient wound healing upon tissue malfunction and has to be tightly controlled by various mechanisms to limit excess responses harmful to host tissues. A myriad of disease conditions ranging from type 2 diabetes (T2D) to neurodegenerative and cardiovascular disorders are now shown to progress due to persistent, unresolved inflammation in metabolic tissues such as adipose, liver, pancreas, muscle, and brain. However, their underlying mechanisms are incompletely understood. The actions of innate and adaptive immune cells in these ailments are increasingly appreciated so much so that a new research area called 'immunometabolism' has emerged. In this review, we will highlight the fundamental roles of various immune cells in adipose tissue during the initiation and progression of obesity-induced inflammation and discuss potential anti-inflammatory therapies from different mechanistic points of view.
引用
收藏
页码:487 / 500
页数:14
相关论文
共 130 条
[1]
Mast cell-orchestrated immunity to pathogens [J].
Abraham, Soman N. ;
St John, Ashley L. .
NATURE REVIEWS IMMUNOLOGY, 2010, 10 (06) :440-452
[2]
Mast cells, macrophages, and crown-like structures distinguish subcutaneous from visceral fat in mice [J].
Altintas, Mehmet M. ;
Azad, Adiba ;
Nayer, Behzad ;
Contreras, Gabriel ;
Zaias, Julia ;
Faul, Christian ;
Reiser, Jochen ;
Nayer, Ali .
JOURNAL OF LIPID RESEARCH, 2011, 52 (03) :480-488
[3]
The roles of insulin and hyperglycemia in sepsis pathogenesis [J].
Andersen, SK ;
Gjedsted, J ;
Christiansen, C ;
Tonnesen, E .
JOURNAL OF LEUKOCYTE BIOLOGY, 2004, 75 (03) :413-421
[4]
IKK-β links inflammation to obesity-induced insulin resistance [J].
Arkan, MC ;
Hevener, AL ;
Greten, FR ;
Maeda, S ;
Li, ZW ;
Long, JM ;
Wynshaw-Boris, A ;
Poli, G ;
Olefsky, J ;
Karin, M .
NATURE MEDICINE, 2005, 11 (02) :191-198
[5]
Interleukin-15 Contributes to the Regulation of Murine Adipose Tissue and Human Adipocytes [J].
Barra, Nicole G. ;
Reid, Sarah ;
MacKenzie, Randy ;
Werstuck, Geoff ;
Trigatti, Bernardo L. ;
Richards, Carl ;
Holloway, Alison C. ;
Ashkar, Ali A. .
OBESITY, 2010, 18 (08) :1601-1607
[6]
Integrative metabolic regulation of peripheral tissue fatty acid oxidation by the Src kinase family member Fyn [J].
Bastie, Claire C. ;
Zong, Haihong ;
Xu, Jun ;
Busa, Bhavin ;
Judex, Stefan ;
Kurland, Irwin J. ;
Pessin, Jeffrey E. .
CELL METABOLISM, 2007, 5 (05) :371-381
[7]
The biology of NKT cells [J].
Bendelac, Albert ;
Savage, Paul B. ;
Teyton, Luc .
ANNUAL REVIEW OF IMMUNOLOGY, 2007, 25 :297-336
[8]
Identification of adipose tissue dendritic cells correlated with obesity-associated insulin-resistance and inducing Th17 responses in mice and patients [J].
Bertola, Adeline ;
Ciucci, Thomas ;
Rousseau, Deborah ;
Bourlier, Virginie ;
Duffaut, Carine ;
Bonnafous, Stephanie ;
Blin-Wakkach, Claudine ;
Anty, Rodolphe ;
Iannelli, Antonio ;
Gugenheim, Jean ;
Tran, Albert ;
Bouloumie, Anne ;
Gual, Philippe ;
Wakkach, Abdelilah .
DIABETES, 2012, 61 (09) :2238-2247
[9]
Myeloid differentiation factor 88-independent Toll-like receptor pathway: Sustaining inflammation or promoting tolerance? [J].
Biswas, Subhra K. ;
Tergaonkarl, Vinay .
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2007, 39 (09) :1582-1592
[10]
CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor [J].
Borg, Natalie A. ;
Wun, Kwok S. ;
Kjer-Nielsen, Lars ;
Wilce, Matthew C. J. ;
Pellicci, Daniel G. ;
Koh, Ruide ;
Besra, Gurdyal S. ;
Bharadwaj, Mandvi ;
Godfrey, Dale I. ;
McCluskey, James ;
Rossjohn, Jamie .
NATURE, 2007, 448 (7149) :44-49