Beckmann rearrangement of ketoximes on solid metaboric acid: a simple and effective procedure

被引：56

作者：

Chandrasekhar, S ^{[1
]}

Gopalaiah, K ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 13期

关键词：

Beckmann; boric acid; formanilide; metaboric acid; rearrangement; solid state;

D O I：

10.1016/S0040-4039(02)00282-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

When ketoximes admixed with solid metaboric acid (formed from boric acid at 100degreesC/0.1 Torr) are heated (similar to 140degreesC/7-42 h), the corresponding amides or lactams are produced in excellent yields (62-92%) via the Beckmann reaction. Aromatic aldoximes undergo both dehydration to the nitrile as well as (non-stereospecific) rearrangement under the above conditions. The absence of solvent, and the mildness and low toxicity of boric acid, characterise the present procedure. CO. 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2455 / 2457

页数：3

共 11 条

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