Nanomaterials for Drug Delivery

被引：449

作者：

Hubbell, Jeffrey A. ^{[1
,2
,3
]}

Chilkoti, Ashutosh ^{[4
,5
]}

机构：

[1] Ecole Polytech Fed Lausanne, Sch Life Sci, Inst Bioengn, CH-1015 Lausanne, Switzerland

[2] Ecole Polytech Fed Lausanne, Sch Engn, CH-1015 Lausanne, Switzerland

[3] Ecole Polytech Fed Lausanne, Sch Basic Sci, Inst Chem Sci & Engn, CH-1015 Lausanne, Switzerland

[4] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA

[5] Duke Univ, Ctr Biol Inspired Mat & Mat Syst, Durham, NC 27708 USA

来源：

SCIENCE | 2012年 / 337卷 / 6092期

关键词：

IN-VIVO; NANOPARTICLES; TUMOR; TRANSPORT; PEPTIDES;

D O I：

10.1126/science.1219657

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Nanometer-scale polymeric materials are increasingly used to surmount the barriers faced by drugs and vaccines on their way to their site of action.

引用

页码：303 / 305

页数：3

共 17 条

[1] Scaling rules for diffusive drug delivery in tumor and normal tissues [J].

Baish, James W. ;

Stylianopoulos, Triantafyllos ;

Lanning, Ryan M. ;

Kamoun, Walid S. ;

Fukumura, Dai ;

Munn, Lance L. ;

Jain, Rakesh K. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (05) :1799-1803

[2] Flexible Filaments for in Vivo Imaging and Delivery: Persistent Circulation of Filomicelles Opens the Dosage Window for Sustained Tumor Shrinkage [J].

Christian, David A. ;

Cai, Shenshen ;

Garbuzenko, Olga B. ;

Harada, Takamasa ;

Zajac, Allison L. ;

Minko, Tamara ;

Discher, Dennis E. .

MOLECULAR PHARMACEUTICS, 2009, 6 (05) :1343-1352

[3] Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles [J].

Davis, Mark E. ;

Zuckerman, Jonathan E. ;

Choi, Chung Hang J. ;

Seligson, David ;

Tolcher, Anthony ;

Alabi, Christopher A. ;

Yen, Yun ;

Heidel, Jeremy D. ;

Ribas, Antoni .

NATURE, 2010, 464 (7291) :1067-U140

[4] A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads [J].

Douglas, Shawn M. ;

Bachelet, Ido ;

Church, George M. .

SCIENCE, 2012, 335 (6070) :831-834

[5] In situ growth of a PEG-like polymer from the C terminus of an intein fusion protein improves pharmacokinetics and tumor accumulation [J].

Gao, Weiping ;

Liu, Wenge ;

Christensen, Trine ;

Zalutsky, Michael R. ;

Chilkoti, Ashutosh .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (38) :16432-16437

[6] Targeted drug delivery to tumor vasculature by a carbohydrate mimetic peptide [J].

Hatakeyama, Shingo ;

Sugihara, Kazuhiro ;

Shibata, Toshiaki K. ;

Nakayama, Jun ;

Akama, Tomoya O. ;

Tamura, Naoaki ;

Wong, Shuk-Man ;

Bobkov, Andrey A. ;

Takano, Yutaka ;

Ohyama, Chikara ;

Fukuda, Minoru ;

Fukuda, Michiko N. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (49) :19587-19592

[7] Antigen delivery to dendritic cells by poly(propylene sulfide) nanoparticles with disulfide conjugated peptides: Cross-presentation and T cell activation [J].

Hirosue, Sachiko ;

Kourtis, Iraklis C. ;

van der Vlies, Andre J. ;

Hubbell, Jeffrey A. ;

Swartz, Melody A. .

VACCINE, 2010, 28 (50) :7897-7906

[8]

MacKay JA, 2009, NAT MATER, V8, P993, DOI [10.1038/NMAT2569, 10.1038/nmat2569]

[9] Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses [J].

Moon, James J. ;

Suh, Heikyung ;

Bershteyn, Anna ;

Stephan, Matthias T. ;

Liu, Haipeng ;

Huang, Bonnie ;

Sohail, Mashaal ;

Luo, Samantha ;

Um, Soong Ho ;

Khant, Htet ;

Goodwin, Jessica T. ;

Ramos, Jenelyn ;

Chiu, Wah ;

Irvine, Darrell J. .

NATURE MATERIALS, 2011, 10 (03) :243-251

[10] Improving Drug Potency and Efficacy by Nanocarrier-Mediated Subcellular Targeting [J].

Murakami, Mami ;

Cabral, Horacio ;

Matsumoto, Yu ;

Wu, Shourong ;

Kano, Mitsunobu R. ;

Yamori, Takao ;

Nishiyama, Nobuhiro ;

Kataoka, Kazunori .

SCIENCE TRANSLATIONAL MEDICINE, 2011, 3 (64)

← 1 2 →