Polyfunctional tetrahydropyrido[2,3-b]pyrazine scaffolds from 4-phenylsulfonyl tetrafluoropyridine

被引：55

作者：

Baron, A

Sandford, G

Slater, R

Yufit, DS

Howard, JAK

Vong, A

机构：

[1] Univ Durham, Dept Chem, Durham DH1 3LE, England

[2] Univ Durham, Chem Crystallog Grp, Durham DH1 3LE, England

[3] GlaxoSmithKline, Harlow CM19 5AW, Essex, England

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 23期

关键词：

D O I：

10.1021/jo051453v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Polyfunctional tetrahydropyrido[2,3-b]pyrazine scaffolds can be synthesized by sequential reaction of pentafluoropyridine with sodium phenylsulfinate and an appropriate diamine. The polyfunctionality possessed by the difluorinated tetrahydropyrido [2,3-b] pyrazine scaffolds was demonstrated in selected model reactions with nucleophiles to give access to various polysubstituted [6,6]-ring fused systems.

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页码：9377 / 9381

页数：5

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