STAM/EAST/Hbp adapter proteins - integrators of signalling pathways

被引：42

作者：

Lohi, O

Lehto, VP ^{[1
]}

机构：

[1] Univ Oulu, Dept Pathol, PL 5000, FIN-90014 Oulu, Finland

[2] Univ Tampere, Dept Pediat, PL 2000, FIN-33521 Tampere, Finland

来源：

FEBS LETTERS | 2001年 / 508卷 / 03期

关键词：

adapter; EAST; endocytosis; Hbp; receptor; STAM;

D O I：

10.1016/S0014-5793(01)03079-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

STAM/EAST/Hbp family of proteins consists of eight members well conserved from yeast to mammals. The basic domain architecture is comprised of an N-terminal Vps27, Hrs and STAM homology domain, a ubiquitin-interacting motif and a central Src homology-3 domain. Vertebrate members also carry an immunoreceptor tyrosine-based activation motif. STAM/EAST/Hbp proteins become tyrosine-phosphorylated by a variety of cytokines and growth factors. STAM 1 and STAM 2A are involved in cytokine-mediated signalling for DNA synthesis and e-myc induction. EAST and STAM 2A/Hbp play a role in receptor-mediated endo- and exocytosis and probably also in the regulation of actin cytoskeleton. Knockout experiments implicate a role for STAM 1 in neural cell survival. A picture is emerging of STAM/EAST/Hbp proteins acting as integrators of thus far mechanistically disparate cellular signalling events. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：287 / 290

页数：4

共 33 条

[1] Hrs is associated with STAM, a signal-transducing adaptor molecule - Its suppressive effect on cytokine-induced cell growth [J].