1,3-Dipolar cycloreversion of a 1,3,4-oxadiazolidine as a controlled azomethine imine surrogate for pyrazolidine synthesis

被引：45

作者：

Khau, VV ^{[1
]}

Martinelli, MJ ^{[1
]}

机构：

[1] LILLY CORP CTR,LILLY RES LABS,CHEM PROC R&D,INDIANAPOLIS,IN 46285

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 25期

关键词：

D O I：

10.1016/0040-4039(96)00836-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Azomethine imines were generated in a controlled manner through a thermally allowed 1,3-dipolar cycloreversion of 1,3,4-oxadiazolidilles and subsequently trapped with dipolarophiles. This method results in the construction of the pyrazolidine heterocycles. A new method for the selective formation of the key semicarbazide substrate, from benzylidene hydrazone, is also disclosed. Copyright (C) 1996 Elsevier Science Ltd.

引用

页码：4323 / 4326

页数：4

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