A chemically labeled cytotoxic agent: Two-photon fluorophore for optical tracking of cellular pathway in chemotherapy

被引:100
作者
Wang, XP
Krebs, LJ
Al-Nuri, M
Pudavar, HE
Ghosal, S
Liebow, C
Nagy, AA
Schally, AV
Prasad, PN [1 ]
机构
[1] SUNY Buffalo, Dept Chem, Photon Res Lab, Buffalo, NY 14260 USA
[2] SUNY Buffalo, Sch Med & Biomed Sci, Dept Physiol, Buffalo, NY 14214 USA
[3] SUNY Buffalo, Sch Med & Biomed Sci, Dept Biophys, Buffalo, NY 14214 USA
[4] SUNY Buffalo, Sch Med & Biomed Sci, Dept Oral Biol, Buffalo, NY 14214 USA
[5] Buffalo Gen Hosp, Buffalo, NY 14203 USA
[6] Laser Photon Technol Inc, Amherst, NY 14221 USA
[7] Vet Affairs Med Ctr, New Orleans, LA 70146 USA
[8] Tulane Univ, Sch Med, New Orleans, LA 70112 USA
关键词
D O I
10.1073/pnas.96.20.11081
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Chemotherapy is commonly used in the treatment of cancers. However, the mechanism of action of many of these agents is not well understood. We present the synthesis of a two-photon fluorophore (C625) and its biological application when chemically linked to a chemotherapeutic agent (AN-152). By using two-photon laser-scanning microscopy, the drug:fluorophore conjugate can be observed directly as it interacts with receptor-positive cell lines. The results of this project visually show the receptor-mediated entry of AN-152 into the cell cytoplasm and subsequently into the nucleus. These observations will allow for better understanding of the drug's therapeutic mechanism, which is a subject of ongoing research aimed at improving present methods for cancer therapy.
引用
收藏
页码:11081 / 11084
页数:4
相关论文
共 29 条
  • [1] HIGHLY POTENT METALLOPEPTIDE ANALOGS OF LUTEINIZING-HORMONE-RELEASING HORMONE
    BAJUSZ, S
    JANAKY, T
    CSERNUS, VJ
    BOKSER, L
    FEKETE, M
    SRKALOVIC, G
    REDDING, TW
    SCHALLY, AV
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (16) : 6313 - 6317
  • [2] HIGHLY POTENT ANALOGS OF LUTEINIZING-HORMONE-RELEASING HORMONE CONTAINING D-PHENYLALANINE NITROGEN-MUSTARD IN POSITION-6
    BAJUSZ, S
    JANAKY, T
    CSERNUS, VJ
    BOKSER, L
    FEKETE, M
    SRKALOVIC, G
    REDDING, TW
    SCHALLY, AV
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (16) : 6318 - 6322
  • [3] ELECTROPHILIC SUBSTITUTION REACTIONS OF TRIPHENYLAMINE
    BAKER, TN
    DOHERTY, WP
    KELLEY, WS
    NEWMEYER, W
    ROGERS, JE
    SPALDING, RE
    WALTER, RI
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1965, 30 (11) : 3714 - &
  • [4] Efficient, two-photon pumped green upconverted cavity lasing in a new dye
    Bhawalkar, JD
    He, GS
    Park, CK
    Zhao, CF
    Ruland, G
    Prasad, PN
    [J]. OPTICS COMMUNICATIONS, 1996, 124 (1-2) : 33 - 37
  • [5] Bhawalkar JD, 1996, SCANNING, V18, P562, DOI 10.1002/sca.4950180805
  • [6] 2-PHOTON LASER SCANNING FLUORESCENCE MICROSCOPY
    DENK, W
    STRICKLER, JH
    WEBB, WW
    [J]. SCIENCE, 1990, 248 (4951) : 73 - 76
  • [7] ACCESSING 3D MEMORY INFORMATION BY MEANS OF NONLINEAR ABSORPTION
    DVORNIKOV, AS
    RENTZEPIS, PM
    [J]. OPTICS COMMUNICATIONS, 1995, 119 (3-4) : 341 - 346
  • [8] THE USE OF LUTEINIZING-HORMONE-RELEASING HORMONE AGONISTS AND ANTAGONISTS IN GYNECOLOGICAL CANCERS
    EMONS, G
    SCHALLY, AV
    [J]. HUMAN REPRODUCTION, 1994, 9 (07) : 1364 - 1379
  • [9] 2-PHOTON ABSORPTION AND OPTICAL-LIMITING PROPERTIES OF NOVEL ORGANIC-COMPOUNDS
    HE, GS
    XU, GC
    PRASAD, PN
    REINHARDT, BA
    BHATT, JC
    DILLARD, AG
    [J]. OPTICS LETTERS, 1995, 20 (05) : 435 - 437
  • [10] ANALOGS OF LUTEINIZING-HORMONE-RELEASING HORMONE CONTAINING CYTOTOXIC GROUPS
    JANAKY, T
    JUHASZ, A
    BAJUSZ, S
    CSERNUS, V
    SRKALOVIC, G
    BOKSER, L
    MILOVANOVIC, S
    REDDING, TW
    REKASI, Z
    NAGY, A
    SCHALLY, AV
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (03) : 972 - 976