Radio frequency (RF) ablation of renal tumours does not produce complete tumour destruction: Results of a phase II study

被引:11
作者
Brausi, M [1 ]
Castagnetti, G [1 ]
Gavioli, M [1 ]
Peracchia, G [1 ]
de Luca, G [1 ]
Olmi, R [1 ]
机构
[1] Osped Sant Agostino Estense, Dept Urol, Modena, Italy
关键词
renal tumour; treatment; prognosis; surgery;
D O I
10.1016/j.eursup.2004.02.004
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Objective: Radio frequency (RF) ablation of small renal tumours has been recently proposed by many urological centres as an alternative treatment to open surgery. However the data on the pathological results on tumour cells after RF are controversial. The objective of this phase II study was to evaluate the pathological changes and the rate of necrosis after intraoperative RF ablation performed immediately before surgery and to observe side effects. Methods: Eight patients with eight renal tumours were treated with RF ablation prior to open surgery. The RITA needle with 9 tines was inserted into the centre of the mass under ultrasound control. The mean patient age was 57.3 years (30-71), the mean tumour diameter was 4.4 cm (2-7.1) and the mean tumour ablation time was 24.7 minutes (18-24). The tissue temperature reached was 100degrees C in all but two cases. A hematoxylin-eosin staining protocol was used by pathologists for tumour examination and the rate of tumour necrosis was defined on slides. Results: The final pathological examination revealed tumour necrosis in all the tumours except one, an angiomyolipoma. Coagulative tumour necrosis varied from 15% to 90% of the specimens (mean tumour necrosis rate was 60%). Complications: mild bleeding after the angiomyolipoma treatment. Conclusions: RF ablation was ineffective for total destruction of renal tumours. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码:14 / 17
页数:4
相关论文
共 18 条
[1]   RADIOFREQUENCY CATHETER ABLATION OF ACCESSORY ATRIOVENTRICULAR CONNECTIONS IN 250 PATIENTS - ABBREVIATED THERAPEUTIC APPROACH TO WOLFF-PARKINSON-WHITE SYNDROME [J].
CALKINS, H ;
LANGBERG, J ;
SOUSA, J ;
ELATASSI, R ;
LEON, A ;
KOU, W ;
KALBFLEISCH, S ;
MORADY, F .
CIRCULATION, 1992, 85 (04) :1337-1346
[2]   Comparison of renal ablation with cryotherapy, dry radiofrequency, and saline augmented radiofrequency in a porcine model [J].
Collyer, WC ;
Landman, J ;
Olweny, EO ;
Andreoni, C ;
Kerbl, K ;
Bostwick, DG ;
Clayman, RV .
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2001, 193 (05) :505-513
[3]   Laparoscopic radiofrequency thermal ablation of renal tissue with and without hilar occlusion [J].
Corwin, TS ;
Lindberg, G ;
Traxer, O ;
Gettman, MT ;
Smith, TG ;
Pearle, MS ;
Cadeddu, JA .
JOURNAL OF UROLOGY, 2001, 166 (01) :281-284
[4]   Radio frequency ablation of renal cell carcinoma: Preliminary clinical experience [J].
de Baere, T ;
Kuoch, V ;
Smayra, T ;
Dromain, C ;
Cabrera, T ;
Court, B ;
Roche, A .
JOURNAL OF UROLOGY, 2002, 167 (05) :1961-1964
[5]   Transperineal radiofrequency interstitial tumor ablation of the prostate: Correlation of magnetic resonance imaging with histopathologic examination [J].
Djavan, B ;
Zlotta, AR ;
Susani, M ;
Heinz, G ;
Shariat, S ;
Silverman, DE ;
Schulman, CC ;
Marberger, M .
UROLOGY, 1997, 50 (06) :986-992
[6]   Renal cell carcinoma: Clinical experience and technical success with radio-frequency ablation of 42 tumors [J].
Gervais, DA ;
McGovern, F ;
Arellano, RS ;
McDougal, WS ;
Mueller, PR .
RADIOLOGY, 2003, 226 (02) :417-424
[7]   Nephron sparing surgery for localized renal cell carcinoma: Impact of tumorsize on patient survival, tumor recurrence and TNM staging [J].
Hafez, KS ;
Fergany, AF ;
Novick, AC .
JOURNAL OF UROLOGY, 1999, 162 (06) :1930-1933
[8]   Transurethral prostate ablation with saline electrode allows controlled production of larger lesions than conventional methods [J].
Hoey, MF ;
Mulier, PM ;
Leveillee, RJ ;
Hulbert, JC .
JOURNAL OF ENDOUROLOGY, 1997, 11 (04) :279-284
[9]  
LIMING S, 2003, UROLOGY S4A, V61, P26
[10]   Incidental renal cell carcinoma - Age and stage characterization and clinical implications: Study of 1092 patients (1982-1997) [J].
Luciani, LG ;
Cestari, R ;
Tallarigo, C .
UROLOGY, 2000, 56 (01) :58-62