Selective androgen receptor modulators in drug discovery: Medicinal chemistry and therapeutic potential

被引：50

作者：

Cadilla, Rodolfo ^{[1
]}

Turnbull, Philip ^{[1
]}

机构：

[1] GlaxoSmithKline Inc, Metab & Viral Drug Discovery, Durham, NC 27705 USA

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2006年 / 6卷 / 03期

关键词：

SARMs; AR; modulation; tissue selectivity; testosterone; clihydrotestosterone; estradiol; hypogonadism;

D O I：

10.2174/156802606776173456

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Modulation of the androgen receptor has the potential to be an effective treatment for hypogonadism, andropause, and associated conditions such as sarcopenia, osteoporosis, benign prostatic hyperplasia, and sexual dysfunction. Side effects associated with classical anabolic steroid treatments have driven the quest for drugs that demonstrate improved therapeutic profiles. Novel, non-steroidal compounds that show tissue selective activity and improved pharmacokinetic properties have been developed. This review provides an overview of current advances in the development of selective androgen receptor modulators (SARMs).

引用

页码：245 / 270

页数：26

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