Insulin, growth factors, and cAMP - Antagonism in the signal transduction pathways

被引：38

作者：

Graves, LM ^{[1
]}

Lawrence, JC ^{[1
]}

机构：

[1] WASHINGTON UNIV,DEPT MOLEC BIOL & PHARMACOL,ST LOUIS,MO 63110

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1996年 / 7卷 / 02期

关键词：

D O I：

10.1016/1043-2760(95)00204-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Depending on the cell type and the response, cAMP may either oppose or facilitate the actions of insulin and/or growth factors that signal via receptor tyrosine kinases. Recent findings indicate that the effects of the cyclic nucleotide are mediated in part by changes in the activities of important elements in the signal transduction path ways utilized by insulin and growth factors.

引用

页码：43 / 50

页数：8

共 76 条

[1] CYCLIC AMP-INCREASING AGENTS INTERFERE WITH CHEMOATTRACTANT INDUCED RESPIRATORY BURST IN NEUTROPHILS AS A RESULT OF THE INHIBITION OF PHOSPHATIDYLINOSITOL 3-KINASE RATHER THAN RECEPTOR-OPERATED CA2+ INFLUX [J].

AHMED, MU ;

HAZEKI, K ;

HAZEKI, O ;

KATADA, T ;

UI, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (40) :23816-23822

[2]

ALALAWI N, 1995, MOL CELL BIOL, V15, P1162

[3] CYCLIC-AMP-DEPENDENT ACTIVATION OF RAP1B [J].

ALTSCHULER, DL ;

PETERSON, SN ;

OSTROWSKI, MC ;

LAPETINA, EG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (18) :10373-10376

[4] BINDING OF SH2 DOMAINS OF PHOSPHOLIPASE-C-GAMMA-1, GAP, AND SRC TO ACTIVATED GROWTH-FACTOR RECEPTORS [J].

ANDERSON, D ;

KOCH, CA ;

GREY, L ;

ELLIS, C ;

MORAN, MF ;

PAWSON, T .

SCIENCE, 1990, 250 (4983) :979-982

[5] THE GTPASE SUPERFAMILY - A CONSERVED SWITCH FOR DIVERSE CELL FUNCTIONS [J].

BOURNE, HR ;

SANDERS, DA ;

MCCORMICK, F .

NATURE, 1990, 348 (6297) :125-132

[6]

BOYNTON AL, 1983, ADV CYCLIC NUCLEOTID, P194

[7] MAPPING OF THE C5A RECEPTOR SIGNAL-TRANSDUCTION NETWORK IN HUMAN NEUTROPHILS [J].

BUHL, AM ;

AVDI, N ;

WORTHEN, GS ;

JOHNSON, GL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (19) :9190-9194

[8] CAMP ANTAGONIZES P21(RAS)-DIRECTED ACTIVATION OF EXTRACELLULAR SIGNAL-REGULATED KINASE-2 AND PHOSPHORYLATION OF MSOS NUCLEOTIDE EXCHANGE FACTOR [J].

BURGERING, BMT ;

PRONK, GJ ;

VANWEEREN, PC ;

CHARDIN, P ;

BOS, JL .

EMBO JOURNAL, 1993, 12 (11) :4211-4220

[9] PROTEIN-KINASE-B (C-AKT) IN PHOSPHATIDYLINOSITOL-3-OH INASE SIGNAL-TRANSDUCTION [J].

BURGERING, BMT ;

COFFER, PJ .

NATURE, 1995, 376 (6541) :599-602

[10] REGULATION OF RAS-MEDIATED SIGNALING - MORE THAN ONE-WAY TO SKIN A CAT [J].

BURGERING, BMT ;

BOS, JL .

TRENDS IN BIOCHEMICAL SCIENCES, 1995, 20 (01) :18-22

← 1 2 3 4 5 6 7 8 →