Schwann Cell to Axon Transfer of Ribosomes: Toward a Novel Understanding of the Role of Glia in the Nervous System

被引:176
作者
Court, Felipe A. [2 ]
Hendriks, William T. J. [1 ,3 ]
MacGillavry, Harold D. [3 ]
Alvarez, Jaime [2 ]
Van Minnen, Jan [3 ,4 ]
机构
[1] Royal Acad Arts & Sci, Netherlands Inst Neurosci, Lab Neurogenerat, NL-1105 BA Amsterdam, Netherlands
[2] Pontificia Univ Catolica Chile, Fac Ciencias Biol, Dept Fisiol, Santiago, Chile
[3] Vrije Univ Amsterdam, Fac Earth & Life Sci, Ctr Neurogen & Cognit Res, Dept Mol & Cellular Neurobiol, NL-1081 HV Amsterdam, Netherlands
[4] Univ Calgary, Fac Med, Dept Cell Biol & Anat, Hotchkiss Brain Inst, Calgary, AB T2N 4N1, Canada
关键词
Schwann cell; ribosomes; Wallerian degeneration; axons; glia; intercellular transport;
D O I
10.1523/JNEUROSCI.2429-08.2008
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Schwann cells play pivotal roles in the development and maintenance of the peripheral nervous system. Here, we show that intact sciatic nerve axons of mice contain a small population of ribosomes, which increases by several orders of magnitude when axons are desomatized (severed from their cell bodies). We furthermore demonstrate, using the Wallerian degeneration slow mouse as a model, that Schwann cells transfer polyribosomes to desomatized axons. These data indicate that Schwann cells have the propensity to control axonal protein synthesis by supplying ribosomes on local basis.
引用
收藏
页码:11024 / 11029
页数:6
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