Total synthesis of ustiloxin D

被引：63

作者：

Cao, B ^{[1
]}

Park, H ^{[1
]}

Joullié, MM ^{[1
]}

机构：

[1] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 04期

关键词：

D O I：

10.1021/ja017277z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The total synthesis of ustiloxin D, a highly potent inhibitor of microtubule assembly, has been achieved. Notable features are the use of nucleophilic aromatic substitution (SNAr) for the construction of a chiral tertiary alkyl-aryl ether linkage, Sharpless asymmetric aminohydroxylation for the formation of the β-hydroxytyrosine moiety, macrolactamization, and regioselective methylation. Copyright © 2002 American Chemical Society.

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页码：520 / 521

页数：2

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