Regulatory T cells and organ transplantation

被引：161

作者：

Waldmann, H ^{[1
]}

Graca, L ^{[1
]}

Cobbold, S ^{[1
]}

Adams, E ^{[1
]}

Tone, M ^{[1
]}

Tone, Y ^{[1
]}

机构：

[1] Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

来源：

SEMINARS IN IMMUNOLOGY | 2004年 / 16卷 / 02期

关键词：

tolerance; transplantation; regulation; privilege;

D O I：

10.1016/j.smim.2003.12.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Empirical studies attempting to explain tolerance to transplanted tissues have demonstrated a regulatory role for CD4+ T-cells. We here propose that regulatory T-cells mediating transplantion tolerance comprise two sets which can functionally complement each other. The CD4+CD25+ "natural regulator" arises in the thymus, and is preoccupied with self-antigens expressed at sites of inflammation. The second, comprising both CD4+CD25+ (FoxP3+) and CD4+CD25- Tr1-like cells are induced by persistent danger-free antigen in the periphery. The role of these cells is to moderate immune responses to prevent tissue destruction while allowing microbial elimination. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：119 / 126

页数：8

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