Long non-coding RNAs and cancer: a new frontier of translational research?

被引：937

作者：

Spizzo, R. ^{[2
]}

Almeida, M. I. ^{[3
]}

Colombatti, A. ^{[2
]}

Calin, G. A. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Unit 1950, Houston, TX 77030 USA

[2] IRCSS Natl Canc Inst, Ctr Riferimento Oncol, Aviano, PN, Italy

[3] Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, Braga, Portugal

来源：

ONCOGENE | 2012年 / 31卷 / 43期

基金：

美国国家卫生研究院;

关键词：

long non-coding RNAs; cancer; online databases; function; TUMOR-SUPPRESSOR GENE; NATURAL ANTISENSE TRANSCRIPTS; CARTILAGE-HAIR HYPOPLASIA; GNAS1 T393C POLYMORPHISM; PROSTATE-SPECIFIC GENE; PROTEIN-CODING RNA; IN-VIVO; DNA METHYLATION; EVOLUTIONARY CONSERVATION; ULTRACONSERVED ELEMENTS;

D O I：

10.1038/onc.2011.621

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tiling array and novel sequencing technologies have made available the transcription profile of the entire human genome. However, the extent of transcription and the function of genetic elements that occur outside of protein-coding genes, particularly those involved in disease, are still a matter of debate. In this review, we focus on long non-coding RNAs (lncRNAs) that are involved in cancer. We define lncRNAs and present a cancer-oriented list of lncRNAs, list some tools (for example, public databases) that classify lncRNAs or that scan genome spans of interest to find whether known lncRNAs reside there, and describe some of the functions of lncRNAs and the possible genetic mechanisms that underlie lncRNA expression changes in cancer, as well as current and potential future applications of lncRNA research in the treatment of cancer.

引用

页码：4577 / 4587

页数：11

共 188 条

[111] GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer [J].

Mourtada-Maarabouni, M. ;

Pickard, M. R. ;

Hedge, V. L. ;

Farzaneh, F. ;

Williams, G. T. .

ONCOGENE, 2009, 28 (02) :195-208

[112] Genetic control by a metabolite binding mRNA [J].

Nahvi, A ;

Sudarsan, N ;

Ebert, MS ;

Zou, X ;

Brown, KL ;

Breaker, RR .

CHEMISTRY & BIOLOGY, 2002, 9 (09) :1043-1049

[113]

Nakayama T, 2007, WORLD J GASTROENTERO, V13, P4473

[114] Organization of the mouse Zjhx1b gene encoding the two-handed zinc finger repressor Smad-interacting protein-1 [J].

Nelles, L ;

Van de Putte, T ;

van Grunsven, L ;

Huylebroeck, D ;

Verschueren, K .

GENOMICS, 2003, 82 (04) :460-469

[115] Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcription [J].

Ng, Laura J. ;

Cropley, Jennifer E. ;

Pickett, Hilda A. ;

Reddel, Roger R. ;

Suter, Catherine M. .

NUCLEIC ACIDS RESEARCH, 2009, 37 (04) :1152-1159

[116] Antisense transcripts at the EMX2 locus in human and mouse [J].

Noonan, FC ;

Goodfellow, PJ ;

Staloch, LJ ;

Mutch, DG ;

Simon, TC .

GENOMICS, 2003, 81 (01) :58-66

[117] Highly parallel SNP genotyping reveals high-resolution landscape of mono-allelic Ube3a expression associated with locus-wide antisense transcription [J].

Numata, Koji ;

Kohama, Chihiro ;

Abe, Kuniya ;

Kiyosawa, Hidenori .

NUCLEIC ACIDS RESEARCH, 2011, 39 (07) :2649-2657

[118] EMX2 is epigenetically silenced and suppresses growth in human lung cancer [J].

Okamoto, J. ;

Hirata, T. ;

Chen, Z. ;

Zhou, H-M ;

Mikami, I. ;

Li, H. ;

Beltran, A. ;

Johansson, M. ;

Coussens, L. M. ;

Clement, G. ;

Shi, Y. ;

Zhang, F. ;

Koizumi, K. ;

Shimizu, K. ;

Jablons, D. ;

He, B. .

ONCOGENE, 2010, 29 (44) :5969-5975

[119] Transduction of HOXD3-antisense into human melanoma cells results in decreased invasive and motile activities [J].

Okubo, Y ;

Hamada, J ;

Takahashi, Y ;

Tada, M ;

Tsutsumida, A ;

Furuuchi, K ;

Aoyama, T ;

Sugihara, T ;

Moriuchi, T .

CLINICAL & EXPERIMENTAL METASTASIS, 2002, 19 (06) :503-511

[120] The regulation of non-coding RNA expression in the liver of mice fed DDC [J].

Oliva, Joan ;

Bardag-Gorce, Fawzia ;

French, Barbara A. ;

Li, Jun ;

French, Samuel W. .

EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2009, 87 (01) :12-19

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