Role of Th1 and Th17 cells in organ-specific autoimmunity

被引：445

作者：

Dardalhon, Valerie ^{[2
]}

Korn, Thomas ^{[1
]}

Kuchroo, Vijay K. ^{[1
]}

Anderson, Ana C. ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Ctr Neurol Dis, Boston, MA 02115 USA

[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Ctr Neurol Dis, Cambridge, MA 02139 USA

来源：

JOURNAL OF AUTOIMMUNITY | 2008年 / 31卷 / 03期

关键词：

Th1; Th17; IL-17; IFN-gamma; Autoimmunity;

D O I：

10.1016/j.jaut.2008.04.017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

CD4(+) IFN-gamma-producing Th1 cells have long been associated with the pathogenesis of many organ-specific autoimmune diseases; however, the observation of disease in mice deficient in molecules involved in Th1 cell differentiation raised the possibility that other effector T cells were responsible for inducing autoimmunity. Recently, a new CD4(+) effector T cell subset that produces IL-17 (Th17) has emerged. The fact that Th17 cells are highly auto-pathogenic has fueled a debate as to what role, if any, Th1 cells play in the induction of tissue inflammation and autoimmune disease. This review will discuss the respective roles of the Th1 and Th17 subsets in organ-specific autoimmunity. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：252 / 256

页数：5

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