Myocyte growth in the failing heart

被引：20

作者：

Kajstura, J ^{[1
]}

Leri, A ^{[1
]}

Castaldo, C ^{[1
]}

Nadal-Ginard, B ^{[1
]}

Anversa, P ^{[1
]}

机构：

[1] New York Med Coll, Dept Med, Cardiovasc Res Inst, Valhalla, NY 10595 USA

来源：

SURGICAL CLINICS OF NORTH AMERICA | 2004年 / 84卷 / 01期

关键词：

D O I：

10.1016/S0039-6109(03)00215-9

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The objective of this article is to provide the reader with a new paradigm of the biology of the adult human heart. The recognition that primitive undifferentiated cells and lineage-committed cells are present in the normal and stressed myocardium strongly suggests that the heart belongs to the group of self-renewing organs. Additionally, the expression of telomerase in amplifying myocytes is enhanced in the overloaded heart, supporting the notion that a significant growth reserve exists in the myocardium. Myocyte hypertrophy is no longer the only form of cell growth in the pathologic heart.

引用

页码：161 / +

页数：18

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