Association between Antimicrobial Consumption and Resistance in Escherichia coli

被引:56
作者
Bergman, Miika [1 ]
Nyberg, Solja T. [1 ]
Huovinen, Pentti [1 ]
Paakkari, Pirkko [2 ]
Hakanen, Antti J. [1 ]
机构
[1] Natl Publ Hlth Inst, Antimicrobial Res Lab, Dept Bacterial & Inflammatory Dis, FI-20520 Turku, Finland
[2] Natl Agcy Med, Helsinki, Finland
基金
芬兰科学院;
关键词
MEDIATED QUINOLONE RESISTANCE; URINARY-TRACT-INFECTIONS; STREPTOCOCCUS-PNEUMONIAE; SULFONAMIDE RESISTANCE; STAPHYLOCOCCUS-AUREUS; ANTIBIOTIC USE; CLONAL GROUP; TRIMETHOPRIM; COMMUNITY; PREVALENCE;
D O I
10.1128/AAC.00856-08
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
During a 9-year study period from 1997 through 2005, the association between antimicrobial resistance rates in Escherichia coli and outpatient antimicrobial consumption was investigated in 20 hospital districts in Finland. A total of 754,293 E. coli isolates, mainly from urine samples, were tested for antimicrobial resistance in 26 clinical microbiology laboratories. The following antimicrobials were studied: ampicillin, amoxicillin-clavulanate, cephalosporins, fluoroquinolones, trimethoprim, trimethoprim-sulfamethoxazole, pivmecillinam, and nitrofurantoin. We applied a protocol used in earlier studies in which the level of antimicrobial consumption over 1 year was compared with the level of resistance in the next year. Statistically significant associations were found for nitrofurantoin use versus nitrofurantoin resistance (P < 0.0001), cephalosporin use versus nitrofurantoin resistance (P = 0.0293), amoxicillin use versus fluoroquinolone resistance (P = 0.0031), and fluoroquinolone use versus ampicillin resistance (P = 0.0046). Interestingly, we found only a few associations between resistance and antimicrobial consumption. The majority of the associations studied were not significant, including the association between fluoroquinolone use and fluoroquinolone resistance.
引用
收藏
页码:912 / 917
页数:6
相关论文
共 28 条
[1]   High prevalence of acquired antimicrobial resistance unrelated to heavy antimicrobial consumption [J].
Bartoloni, A ;
Bartalesi, F ;
Mantella, A ;
Dell'Amico, E ;
Roselli, M ;
Strohmeyer, M ;
Barahona, HG ;
Barrón, VP ;
Paradisi, F ;
Rossolini, GM .
JOURNAL OF INFECTIOUS DISEASES, 2004, 189 (07) :1291-1294
[2]   Effect of macrolide consumption on erythromycin resistance in Streptococcus pyogenes in Finland in 1997-2001 [J].
Bergman, M ;
Huikko, S ;
Pihlajamäki, M ;
Laippala, P ;
Palva, E ;
Huovinen, P ;
Seppälä, H .
CLINICAL INFECTIOUS DISEASES, 2004, 38 (09) :1251-1256
[3]   Macrolide and azithromycin use are linked to increased macrolide resistance in Streptococcus pneumoniae [J].
Bergman, Miika ;
Huikko, Solja ;
Huovinen, Pentti ;
Paakkari, Pirkko ;
Seppala, Helena .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (11) :3646-3650
[4]   Risk factors for trimethoprim-sulfamethoxazole resistance in patients with acute uncomplicated cystitis [J].
Colgan, Richard ;
Johnson, James R. ;
Kuskowski, Michael ;
Gupta, Kalpana .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (03) :846-851
[5]   Persistence of sulphonamide resistance in Escherichia coli in the UK despite national prescribing restriction [J].
Enne, VI ;
Livermore, DM ;
Stephens, P ;
Hall, LMC .
LANCET, 2001, 357 (9265) :1325-1328
[6]  
*EUR ANT RES SURV, 2006, EARSS ANN REP
[7]   Antibiotic use and Escherichia coli resistance trends for quinolones and cotrimoxazole in Sweden [J].
Farra, A ;
Skoog, G ;
Wallén, L ;
Kahlmeter, G ;
Kronvall, G ;
Sörberg, M .
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 2002, 34 (06) :449-455
[8]  
*FINN SOC NEPHR FI, UR TRACT INF CURR CA
[9]   Increasing resistance to fluoroquinolones in Escherichia coli from urinary tract infections in The Netherlands [J].
Goettsch, W ;
van Pelt, W ;
Nagelkerke, N ;
Hendrix, MGR ;
Buiting, AGM ;
Petit, PL ;
Sabbe, LJM ;
van Griethuysen, AJA ;
de Neeling, AJ .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2000, 46 (02) :223-228
[10]   The relationship between primary care antibiotic prescribing and bacterial resistance in adults in the community: a controlled observational study using individual patient data [J].
Hay, AD ;
Thomas, M ;
Montgomery, A ;
Wetherell, M ;
Lovering, A ;
McNulty, C ;
Lewis, D ;
Carron, B ;
Henderson, E ;
MacGowan, A .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2005, 56 (01) :146-153