Catalysis of DNA cleavage by lanthanide complexes with nucleophilic or intercalating ligands and their kinetic characterization

被引：102

作者：

Rammo, J ^{[1
]}

Hettich, R ^{[1
]}

Roigk, A ^{[1
]}

Schneider, HJ ^{[1
]}

机构：

[1] UNIV SAARLAND,FR ORGAN CHEM,D-66041 SAARBRUCKEN,GERMANY

来源：

CHEMICAL COMMUNICATIONS | 1996年 / 01期

关键词：

D O I：

10.1039/cc9960000105

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The catalysis of plasmid ds-DNA cleavage by lanthanoid cations and their complexes is characterized by saturation kinetics; addition of polyamines or cryptand does not hinder catalysis, which can be enhanced to a total factor of 10(7) by alcoholic co-substrates such as glycerol, or by intercalating ligands.

引用

页码：105 / 107

页数：3

共 22 条

[1]

ARNAUDNEU F, 1994, CHEM SOC REV, P235

[2] METAL-ACTIVATED HYDROLYTIC CLEAVAGE OF DNA [J].

BASILE, LA ;

RAPHAEL, AL ;

BARTON, JK .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (24) :7550-7551

[3] EQUILIBRIUM DIALYSIS STUDIES OF POLYAMINE BINDING TO DNA [J].

BRAUNLIN, WH ;

STRICK, TJ ;

RECORD, MT .

BIOPOLYMERS, 1982, 21 (07) :1301-1314

[4] CO(III) COMPLEX PROMOTED HYDROLYSIS OF PHOSPHATE DIESTERS - COMPARISON IN REACTIVITY OF RIGID CIS-DIAQUOTETRAAZACOBALT(III) COMPLEXES [J].

CHIN, J ;

BANASZCZYK, M ;

JUBIAN, V ;

ZOU, X .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (01) :186-190

[5] THERMAL DEGRADATION OF NUCLEIC ACIDS [J].

EIGNER, J ;

BOEDTKER, H ;

MICHAELS, G .

BIOCHIMICA ET BIOPHYSICA ACTA, 1961, 51 (01) :165-&

[6]

Fersht A. R., 1977, Enzyme Structure and Mechanism

[7] SYNTHESIS AND CHEMICAL PROPERTIES OF LANTHANIDE CRYPTATES [J].

GANSOW, OA ;

KAUSAR, AR ;

TRIPLETT, KM ;

WEAVER, MJ ;

YEE, EL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1977, 99 (21) :7087-7089

[8] CLEAVAGE OF DOUBLE HELICAL DNA BY (METHIDIUMPROPYL-EDTA)IRON(II) [J].

HERTZBERG, RP ;

DERVAN, PB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1982, 104 (01) :313-315

[9] EFFICIENT AND OXYGEN-INDEPENDENT HYDROLYSIS OF SINGLE-STRANDED-DNA BY CERIUM(IV) ION [J].

KOMIYAMA, M ;

TAKEDA, N ;

TAKAHASHI, Y ;

UCHIDA, H ;

SHIIBA, T ;

KODAMA, T ;

YASHIRO, M .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1995, (02) :269-274

[10]

Matsumoto Y, 1992, Nucleic Acids Symp Ser, P33

← 1 2 3 →