Synthesis and binding affinity of new muscarinic ligands structurally related to oxotremorine

被引：7

作者：

Conti, P

Dallanoce, C

DeAmici, M

De Micheli, C

Ebert, B

机构：

[1] UNIV MILAN, IST CLIN FARMACEUT & TOSSICOL, I-20131 MILAN, ITALY

[2] ROYAL DANISH SCH PHARM, DEPT MED CHEM, PHARMABIOTEC RES CTR, DK-2100 COPENHAGEN, DENMARK

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(97)00150-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and radioligand binding assays of a group of muscarinic ligands related to oxotremorine are reported. The new compounds displayed binding affinities comparable to those of the parent molecule with the exception of the trimethylammonium salt 6, which behaved as a fill muscarinic agonist and showed a pronounced selectivity for M-2 versus M-1 muscarinic receptor subtypes. (C) 1997 Elsevier Science Ltd.

引用

页码：1033 / 1036

页数：4

共 20 条

[1] POSITION-5 AT THE OXOTREMORINE SKELETON AS THE STEERING POSITION FOR ACTIVITY AT THE MUSCARINIC RECEPTORS [J].