Uniform Rattle-type Hollow Magnetic Mesoporous Spheres as Drug Delivery Carriers and their Sustained-Release Property

被引：433

作者：

Zhao, Wenru ^{[1
]}

Chen, Hangrong ^{[2
]}

Li, Yongsheng ^{[1
]}

Li, Liang ^{[1
]}

Lang, Meidong ^{[1
]}

Shi, Jianlin ^{[1
,2
]}

机构：

[1] E China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

来源：

ADVANCED FUNCTIONAL MATERIALS | 2008年 / 18卷 / 18期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

D O I：

10.1002/adfm.200701317

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel kind of rattle-type hollow magnetic mesoporous sphere (HMMS) with Fe3O4 particles encapsulated in the cores of mesoporous silica microspheres has been successfully fabricated by sol-gel reactions on hematite particles followed by cavity generation with hydrothermal treatment and H, reduction. Such a structure has the merits of both enhanced drug-loading capacity and a significant magnetization strength. The prepared HMMSs realize a relatively high storage capacity up to 302 mg g(-1) when ibuprofen is used as a model drug, and the IBU-HMMS system has a sustained-re lease property, which follows a Fick's law.

引用

页码：2780 / 2788

页数：9

共 43 条

[1] Development of magnetic nanostructured silica-based materials as potential vectors for drug-delivery applications [J].