Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans

被引：371

作者：

Doonan, Ryan ^{[1
]}

McElwee, Joshua J. ^{[1
]}

Matthijssens, Filip ^{[2
]}

Walker, Glenda A. ^{[1
]}

Houthoofd, Koen ^{[2
]}

Back, Patricia ^{[2
]}

Matscheski, Andrea ^{[1
]}

Vanfleteren, Jacques R. ^{[2
]}

Gems, David ^{[1
]}

机构：

[1] UCL, Inst Hlth Aging & Res, Dept Genet Evolut & Environm, London WC1E 6BT, England

[2] Univ Ghent, Dept Biol, B-9000 Ghent, Belgium

来源：

GENES & DEVELOPMENT | 2008年 / 22卷 / 23期

基金：

美国国家卫生研究院; 英国惠康基金;

关键词：

Aging; Caenorhabditis elegans; free radical; superoxide dismutase; insulin/IGF-1; signaling; genetics;

D O I：

10.1101/gad.504808

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The superoxide radical (O-2(-)) has long been considered a major cause of aging. O-2(-) in cytosolic, extracellular, and mitochondrial pools is detoxified by dedicated superoxide dismutase (SOD) isoforms. We tested the impact of each SOD isoform in Caenorhabditis elegans by manipulating its five sod genes and saw no major effects on life span. sod genes are not required for daf-2 insulin/IGF-1 receptor mutant longevity. However, loss of the extracellular Cu/ZnSOD sod-4 enhances daf-2 longevity and constitutive diapause, suggesting a signaling role for sod-4. Overall, these findings imply that O-2(-) is not a major determinant of aging in C. elegans.

引用

页码：3236 / 3241

页数：6

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