Critical review of the role of HTS in drug discovery

被引:160
作者
Macarron, R [1 ]
机构
[1] GlaxoSmithKline Inc, Collegeville, PA 19426 USA
关键词
D O I
10.1016/j.drudis.2006.02.001
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:277 / 279
页数:3
相关论文
共 20 条
[11]   The druggable genome [J].
Hopkins, AL ;
Groom, CR .
NATURE REVIEWS DRUG DISCOVERY, 2002, 1 (09) :727-730
[12]  
LANDERS P, 2004, WALL STREET J 0224
[13]   Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings [J].
Lipinski, CA ;
Lombardo, F ;
Dominy, BW ;
Feeney, PJ .
ADVANCED DRUG DELIVERY REVIEWS, 1997, 23 (1-3) :3-25
[14]  
MOORE SD, 1995, WALL STREET J 1020
[15]   Design of signal windows in high throughput screening assays for drug discovery [J].
Sittampalam, GS ;
Iversen, PW ;
Boadt, JA ;
Kahl, SD ;
Bright, S ;
Zock, JM ;
Janzen, WP ;
Lister, MD .
JOURNAL OF BIOMOLECULAR SCREENING, 1997, 2 (03) :159-169
[16]  
Spencer RW, 1998, BIOTECHNOL BIOENG, V61, P61, DOI 10.1002/(SICI)1097-0290(199824)61:1<61::AID-BIT11>3.0.CO
[17]  
2-C
[18]   A standard operating procedure for assessing liquid handler performance in high-throughput screening [J].
Taylor, PB ;
Ashman, S ;
Baddeley, SM ;
Bartram, SL ;
Battle, CD ;
Bond, BC ;
Clements, YM ;
Gaul, NJ ;
McAllister, WE ;
Mostacero, JA ;
Ramon, F ;
Wilson, JM ;
Hertzberg, RP ;
Pope, AJ ;
Macarron, R .
JOURNAL OF BIOMOLECULAR SCREENING, 2002, 7 (06) :554-569
[19]   Diversity screening versus focussed screening in drug discovery [J].
Valler, MJ ;
Green, D .
DRUG DISCOVERY TODAY, 2000, 5 (07) :286-293
[20]   High-throughput screening for kinase inhibitors [J].
von Ahsen, O ;
Bömer, U .
CHEMBIOCHEM, 2005, 6 (03) :481-490