Signaling and cell death in lymphocytes

被引：15

作者：

Flavell, RA

Dong, C

Davis, RJ

机构：

[1] Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA

[3] Univ Massachusetts, Sch Med, Dept Biochem & Mol Biol, Program Mol Med, Worcester, MA 01605 USA

[4] Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Worcester, MA 01605 USA

来源：

INFLAMMATION RESEARCH | 2002年 / 51卷 / 02期

关键词：

T lymphocytes; Th1/Th2; transcription factor; MAP kinases;

D O I：

10.1007/BF02684006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

After activation, CD4 helper T (Th) cells differentiate into Th1 or Th2 effector cells. These two subsets produce distinct profiles of cytokines and regulate different immune responses. Here we discuss transcription factors and signaling pathways that are selectively expressed or activated in Th1 and Th2 cells to regulate cytokine gene expression, cell proliferation and apoptosis.

引用

收藏

页码：80 / 82

页数：3

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