Potential new anti-human immunodeficiency virus type 1 compounds depress virus replication in cultured human macrophages

被引：44

作者：

Ewart, GD

Nasr, N

Naif, H

Cox, GB

Cunningham, AL

Gage, PW

机构：

[1] Australian Natl Univ, Biotron Ltd, Canberra, ACT 2601, Australia

[2] Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia

[3] Westmead Millenium Inst, Westmead, NSW 2145, Australia

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 06期

关键词：

D O I：

10.1128/AAC.48.6.2325-2330.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report that the amiloride analogues 5-(N,N'-hexamethylene)amiloride and 5-(N,N'-dimethyl)amiloride inhibit, at micromolar concentrations, the replication of human immunodeficiency virus type 1 (HIV-1) in cultured human blood monocyte-derived macrophages. These compounds also inhibit the in vitro activities of the HIV-1 Vpu protein and might represent lead compounds for a new class of anti-HIV-1 drugs.

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页码：2325 / 2330

页数：6

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