Noninvasive Native Fluorescence Imaging of Head and Neck Tumors

被引：19

作者：

Katz, A. ^{[1
]}

Savage, Howard E. ^{[2
]}

Schantz, Stimson P. ^{[3
]}

McCormick, Steven A. ^{[2
]}

Alfano, R. R. ^{[1
]}

机构：

[1] CUNY, New York State Ctr Adv Technol Ultrafast Photon, Inst Ultrafast Spect & Lasers, New York, NY 10031 USA

[2] New York Eye & Ear Infirm, Dept Pathol, New York, NY 10003 USA

[3] New York Eye & Ear Infirm, Dept Otolaryngol, New York, NY 10003 USA

来源：

TECHNOLOGY IN CANCER RESEARCH & TREATMENT | 2002年 / 1卷 / 01期

关键词：

D O I：

10.1177/153303460200100102

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Fluorescence images were acquired from ex vivo head and neck tumor specimens. The excitation and emission wavelength combinations were selected to image emission from native tissue fluorophores (collagen, tryptophan, elastin and nicotinamide adenine dinucleotide). Two dimensional intensity ratio maps were generated from the fluorescence images and compared to histology images. The ratio maps accurately distinguished the regions of tumor from normal tissue in the specimens. Additional features, such as collagen capsules, blood vessels, mucus glands and muscles were evident in the fluorescence images.

引用

页码：9 / 15

页数：7

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