Murine T Cell-Derived Contractile Activity for Bronchial Smooth Muscle Cells

被引：3

作者：

Abe, Akemi

Koyama, Satoshi

Ohtomo, Takayuki ^{[2
]}

Kitamura, Noriko ^{[3
]}

Kaminuma, Osamu ^{[3
]}

Mori, Akio ^{[1
]}

机构：

[1] Sagamihara Natl Hosp, Clin Res Ctr Allergy & Rheumatol, Natl Hosp Org, Minami Ku, Sagamihara, Kanagawa 2520392, Japan

[2] Tokyo Univ Pharm & Life Sci, Dept Pharmacotherapeut, Tokyo, Japan

[3] Tokyo Metropolitan Inst Med Sci, Dept Allergy & Immunol, Tokyo 113, Japan

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 2012年 / 158卷

基金：

日本学术振兴会;

关键词：

Bronchial smooth muscle cells; Collagen gel; Contraction assay; Helper T cell; Late asthmatic response; LEUKOTRIENE RECEPTOR ANTAGONIST; LATE ASTHMATIC RESPONSE; GENE-RELATED PEPTIDE; AIRWAY HYPERRESPONSIVENESS; BRONCHOCONSTRICTION; INTERLEUKIN-5; EOSINOPHILS; ATTENUATION; LYMPHOCYTES; INHALATION;

D O I：

10.1159/000337743

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Background: Adoptive transfer of helper T (Th) cells conferred a late asthmatic response upon antigen challenge. A possible production of a contractile activity for bronchial smooth muscle (BSM) by activated Th cells was examined. Method: Murine Th clones were stimulated with immobilized anti-CD3 antibody in the presence or absence of anti-CD28 antibody. Culture supernatants were dialyzed and then applied to the collagen gels containing cultured human BSM cells. Results: Culture supernatants of activated but not resting murine Th clones that conferred a late asthmatic response, induced the contraction of human BSM cell-containing collagen gels. Conclusion: Activated Th cells produce a contractile activity for BSM in vitro. Copyright (C) 2012 S. Karger AG, Basel

引用

页码：7 / 10

页数：4

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