Increased levels of soluble triggering receptor expressed on myeloid cells-1 in patients with acute pancreatitis

被引：85

作者：

Yasuda, Takeo ^{[1
]}

Takeyama, Yoshifumi ^{[1
]}

Ueda, Takashi ^{[1
]}

Shinzeki, Makoto ^{[2
]}

Sawa, Hidehiro ^{[2
]}

Takahiro, Nakajirna ^{[2
]}

Kamei, Keiko ^{[1
]}

Ku, Yonson ^{[2
]}

Kuroda, Yoshikazu ^{[2
]}

Ohyanagi, Harumasa ^{[1
]}

机构：

[1] Kinki Univ, Sch Med, Dept Surg, Osakasayama, Japan

[2] Kobe Univ, Grad Sch Med Sci, Dept Surg, Kobe, Hyogo, Japan

来源：

CRITICAL CARE MEDICINE | 2008年 / 36卷 / 07期

关键词：

acute pancreatitis; TREM-1; sTREM-1; mediator inflammatory response; early organ dysfunction;

D O I：

10.1097/CCM.0b013e31817b8824

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Objective: To determine the contribution of triggering receptor expressed on myeloid cells (TREM)-1 in acute pancreatitis (AP). Design: Prospective study. Setting: General intensive care unit at Kobe University Hospital. Patients. Forty-eight patients with AP and seven patients as control. Interventions. None. Measurements and Main Results, We measured serum concentrations of soluble TREM-1 (sTREM-1) at the time of admission by enzyme-linked immunoadsorbent assay. Serum sTREM-1 levels increased significantly in AP (63 +/- 11 pg/mL) and correlated with Ranson score (R = .628, p < .001) and Acute Physiology and Chronic Health Evaluation II score (R = .504, p < .001). Serum TREM-1 levels were higher in patients with early organ dysfunction (which occurred within 7 days after onset) than those without early organ dysfunction (101 +/- 19 vs. 25 +/- 4 pg/mL, p < .001). Incidences of early organ dysfunction in patients whose serum sTREM-1 levels were <= 40 and >40 pg/mL were 17% and 83%, respectively (p < .001). The usefulness of serum sTREM-1 in detecting early organ dysfunction was superior to that of C-reactive protein, interleukin-6, interleukin-8, Ranson score, and Acute Physiology and Chronic Health Evaluation II score. Serum sTREM-1 levels decreased with resolution of early organ dysfunction. Conclusions. Serum sTREM-1 levels were significantly increased and correlated with disease severity and early organ dysfunction in patients with AP. Serum sTREM-1 level may be a useful marker for early organ dysfunction in AP.

引用

页码：2048 / 2053

页数：6

共 34 条

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