Histamine, polyamines, and cancer

被引：81

作者：

Medina, MA ^{[1
]}

Quesada, AR ^{[1
]}

de Castro, IN ^{[1
]}

Sánchez-Jiménez, F ^{[1
]}

机构：

[1] Univ Malaga, Fac Ciencias, Lab Bioquim & Biol Mol, E-29071 Malaga, Spain

来源：

BIOCHEMICAL PHARMACOLOGY | 1999年 / 57卷 / 12期

关键词：

histamine; polyamine; tumour; histidine decarboxylase (HDC); ornithine decarboxylase (ODC); aromatic L-amino acid decarboxylase (DDC); monofluoromethylhistidine (MFMH);

D O I：

10.1016/S0006-2952(99)00005-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Mammalian ornithine decarboxylase and histidine decarboxylase present common structural and Functional features, and their products also share pharmacological and physiological properties. Although accumulated evidence pointed for years to a direct involvement of polyamines and histamine in tumour growth, it has been only in the last few years that new molecular data have contributed to the clarification of this topic. The aim of this commentary is to review the molecular grounds of the rule of histamine and polyamines in cancer and to point to possible directions for future research in emerging areas of interest. (C) 1999 Elsevier Science Inc.

引用

页码：1341 / 1344

页数：4

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