CD4 cell counts in human immunodeficiency virus-negative patients with tuberculosis

被引:69
作者
Jones, BE
Oo, MM
Taikwel, EK
Qian, DJ
Kumar, A
Maslow, ER
Barnes, PF
机构
[1] UNIV SO CALIF,SCH MED,DEPT MED,LOS ANGELES,CA 90033
[2] UNIV SO CALIF,SCH MED,DEPT PREVENT MED,LOS ANGELES,CA 90033
关键词
D O I
10.1093/clinids/24.5.988
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We evaluated 85 human immunodeficiency virus (HIV)-negative patients with tuberculosis for clinical features and CD4 cell counts. Thirty-seven patients had low CD4 cell counts (mean +/- SD, 341 +/- 116 cells/mu L), and 48 patients had normal CD4 cell counts (mean +/- SD, 830 +/- 254 cells/mu L). CD4 cell counts were most strongly correlated with total lymphocyte counts (r = 0.84). If total lymphocyte count was excluded, depressed CD4 cell counts were significantly associated with low serum albumin levels, extensive pulmonary disease, low body-mass index, and low hematocrit. Of these four variables, multivariate linear discriminant analysis revealed that the serum albumin level was the best single predictor of low CD4 cell counts and that the other three variables did not improve predictive value. Because these four variables are markers of severe tuberculosis, these findings suggest that disease severity is associated with greater depression of the total lymphocyte and CD4 cell counts. The CD I cell counts returned to normal levels in most patients after 1 month of therapy.
引用
收藏
页码:988 / 991
页数:4
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