Translation initiation factors and their relevance in cancer

被引：53

作者：

de la Parra, Columba

Walters, Beth A.

Geter, Phillip

Schneider, Robert J. ^{[1
]}

机构：

[1] NYU, Sch Med, Dept Microbiol, New York, NY 10016 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2018年 / 48卷

基金：

美国国家卫生研究院;

关键词：

EMBRYONIC STEM-CELLS; EUKARYOTIC TRANSLATION; MESSENGER-RNA; BREAST-CANCER; MALIGNANT-TRANSFORMATION; DIFFERENTIAL REGULATION; DRIVEN TRANSLATION; KINASE INHIBITORS; PROTEIN-SYNTHESIS; SUBUNIT-C;

D O I：

10.1016/j.gde.2017.11.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Deregulation of several translation initiation factors occurs in numerous types of cancers. Translation initiation factors are not merely ancillary players in cancer development and progression, but rather, they are key participants in cellular transformation and tumor development. In fact, the altered expression of translation initiation factors is involved in cancer cell survival, metastasis and tumor angiogenesis. Although the exact mechanisms remain to be fully characterized, translation initiation factors comprise novel targets for pharmacologic intervention. Here we review the most recently established roles of initiation factors in cancer development and progression, as well as unique methods used to study translational regulation.

引用

页码：82 / 88

页数：7

共 49 条

[1]

Inhibition of 4EBP phosphorylation mediates the cytotoxic effect of mechanistic target of rapamycin kinase inhibitors in aggressive B-cell lymphomas [J].