Differences in interferon alpha and beta signaling - Interferon beta selectively induces the interaction of the alpha and beta(L) subunits of the Type I interferon receptor

被引:96
作者
Platanias, LC
Uddin, S
Domanski, P
Colamonici, OR
机构
[1] UNIV ILLINOIS,HEMATOL ONCOL SECT,MBRB,DEPT MED,CHICAGO,IL 60607
[2] W SIDE VET AFFAIRS HOSP,CHICAGO,IL 60607
[3] LOYOLA UNIV,DIV HEMATOL ONCOL,MAYWOOD,IL 60153
[4] VET AFFAIRS EDWARD HINES JR HOSP,DIV HEMATOL ONCOL,MAYWOOD,IL 60153
[5] UNIV TENNESSEE,DEPT PATHOL,MEMPHIS,TN 38163
关键词
D O I
10.1074/jbc.271.39.23630
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
All Type I interferons (IFN alpha, IFN beta, IFN omega) bind to the Type I IFN receptor (IFNR) and elicit a common set of signaling events, including activation of the Jak/Stat and IRS pathways. However, IFN beta selectively induces the association of the alpha subunit of the Type I IFNR with p100, a tyrosyl phosphoprotein, to transduce IFN beta-specific signals. Using antibodies raised against the different components of the Type I IFNR, we identified p100 as the long form of the beta subunit (beta(L) subunit) of the Type I IFNR, This was also confirmed in experiments with mouse L-929 cells transfected with truncated forms of beta(L). Thus, IFN beta stimulation of human cells or mouse L-929 transfectants expressing the human alpha and beta(L) subunits, selectively induces the formation of a signaling complex containing the alpha and beta(L) subunits of the receptor, The IFN beta-regulated interaction of the alpha and beta(L) chains is rapid and transient and follows a similar time course with the tyrosine phosphorylation of these receptor components, These data demonstrate that the signaling specificity for different Type I IFNs is established early in the signaling cascade, at the receptor level, and results from distinct interactions between components of the Type I IFNR.
引用
收藏
页码:23630 / 23633
页数:4
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