Transgenic models to assess the pathogenic actions of cytokines in the central nervous system

被引：87

作者：

Campbell, IL ^{[1
]}

Stalder, AK ^{[1
]}

Chiang, CS ^{[1
]}

Bellinger, R ^{[1
]}

Heyser, CJ ^{[1
]}

Steffensen, S ^{[1
]}

Masliah, E ^{[1
]}

Powell, HC ^{[1
]}

Gold, LH ^{[1
]}

Henriksen, SJ ^{[1
]}

Siggins, GR ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO, DEPT PATHOL, LA JOLLA, CA 92093 USA

来源：

MOLECULAR PSYCHIATRY | 1997年 / 2卷 / 02期

关键词：

neurological disorder; transgenic mice; cytokine; astrocyte; GFAP;

D O I：

10.1038/sj.mp.4000225

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In order to better understand the actions of proinflammatory cytokines in the mammalian CNS, a transgenic approach was employed in which the expression of IL-6, IL-3 or TNF-alpha was targeted to astrocytes in the intact CNS of mice, Transgenic mice exhibited distinct chronic-progressive neurological disorders with neurodegeneration and cognitive decline due to IL-6 expression, macrophage/microglial-mediated primary demyelination with motor impairment due to IL-3 expression and lymphocytic meningoencephalomyelitis with paralysis induced by TNF-alpha expression, Thus, expression of specific cytokines alone in the intact CNS results in unique neuropathological alterations and functional impairments, thereby directly implicating these mediators in the pathogenesis of CNS disease.

引用

页码：125 / 129

页数：5

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