redD and actII-ORF4, pathway-specific regulatory genes for antibiotic production in Streptomyces coelicolor A3(2), are transcribed in vitro by an RNA polymerase holoenzyme containing sigma(hrdD)

被引：35

作者：

Fujii, T ^{[1
]}

Gramajo, HC ^{[1
]}

Takano, E ^{[1
]}

Bibb, MJ ^{[1
]}

机构：

[1] JOHN INNES CTR PLANT SCI RES, DEPT GENET, NORWICH NR4 7UH, NORFOLK, ENGLAND

来源：

JOURNAL OF BACTERIOLOGY | 1996年 / 178卷 / 11期

关键词：

D O I：

10.1128/jb.178.11.3402-3405.1996

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

redd and actII-ORF4, regulatory genes required for synthesis of the antibiotics undecylprodigiosin and actinorhodin by Streptomyces coelicolor A3(2), were transcribed in vitro by an RNA polymerase holoenzyme containing sigma(hrdD). Disruption of hrdD had no effect on antibiotic production, indicating that redD and actII-ORF4 are transcribed in vivo by at least one other RNA polymerase holoenzyme. These data provide the first experimental evidence that HrdD can function as a sigma factor.

引用

页码：3402 / 3405

页数：4

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