Angiotensin II antagonism and pre-glomerular arterial wall dimensions in the kidney of the spontaneously hypertensive rat

被引:4
作者
Anderson, WP [1 ]
Kett, MM [1 ]
Alcorn, D [1 ]
Bertram, JF [1 ]
机构
[1] UNIV MELBOURNE,DEPT ANAT & CELL BIOL,MELBOURNE,VIC,AUSTRALIA
关键词
angiotensin II receptors; interlobular artery; arcuate artery; stereology; wall:lumen ratio;
D O I
10.3109/10641969709083199
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The effects of the angiotensin II type 1 receptor antagonist TCV-116 on the wall dimensions of the interlobular and arcuate arteries have been studied. SHR rats were treated with TCV-116 between 4 and 10 weeks, at which time their kidneys were perfusion-fixed and examined using stereological techniques. TCV-116 reduced arterial pressure and left ventricle/body weight ratio, but did not reduce renal arterial wall dimensions. For both arcuate and interlobular arteries, wall density/kidney ratio was significantly greater in the TCV-116 treated SHR than in untreated SHR and wall:lumen ratio was also significantly greater for the interlobular arteries in the TCV-116 treated rats. These findings are similar to those obtained previously using enalapril, and indicate that hypertrophy of the walls of these intra-renal arteries is not secondary to the elevated arterial pressure, unlike in other vascular beds.
引用
收藏
页码:965 / 979
页数:15
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