Autophagy in inflammation, infection, neurodegeneration and cancer

被引：186

作者：

Arroyo, Daniela S. ^{[1
]}

Gaviglio, Emilia A. ^{[1
]}

Peralta Ramos, Javier M. ^{[1
]}

Bussi, Claudio ^{[1
]}

Rodriguez-Galan, Maria C. ^{[1
]}

Iribarren, Pablo ^{[1
]}

机构：

[1] Univ Nacl Cordoba, CONICET, Fac Ciencias Quim, Ctr Invest Bioquim Clin & Inmunol CIBICI,Dept Bio, RA-5000 Cordoba, Argentina

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2014年 / 18卷 / 01期

关键词：

Autophagy; ATG; Beclin; 1; Neuroinflammation; Diseases; CENTRAL-NERVOUS-SYSTEM; GROUP-A STREPTOCOCCUS; INDUCED CELL-DEATH; IMMUNE-RESPONSES; DENDRITIC CELLS; MYCOBACTERIUM-TUBERCULOSIS; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; CROHNS-DISEASE; BECLIN;

D O I：

10.1016/j.intimp.2013.11.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

In its classical form, autophagy is an essential, homeostatic process by which cytoplasmic components are degraded in a double-membrane-bound autophagosome in response to starvation. Paradoxically, although autophagy is primarily a protective process for the cell, it can also play a role in cell death. The roles of autophagy bridge both the innate and adaptive immune systems and autophagic dysfunction is associated with inflammation, infection, neurodegeneration and cancer. In this review, we discuss the contribution of autophagy to inflammatory, infectious and neurodegenerative diseases, as well as cancer. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：55 / 65

页数：11

共 167 条

[1]

Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy [J].

Alonso, Sylvie ;

Pethe, Kevin ;

Russell, David G. ;

Purdy, Georgiana E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (14) :6031-6036

[2]

Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma [J].

Amaravadi, Ravi K. ;

Yu, Duonan ;

Lum, Julian J. ;

Bui, Thi ;

Christophorou, Maria A. ;

Evan, Gerard I. ;

Thomas-Tikhonenko, Andrei ;

Thompson, Craig B. .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (02) :326-336

[3]

Principles and Current Strategies for Targeting Autophagy for Cancer Treatment [J].

Amaravadi, Ravi K. ;

Lippincott-Schwartz, Jennifer ;

Yin, Xiao-Ming ;

Weiss, William A. ;

Takebe, Naoko ;

Timmer, William ;

DiPaola, Robert S. ;

Lotze, Michael T. ;

White, Eileen .

CLINICAL CANCER RESEARCH, 2011, 17 (04) :654-666

[4]

[Anonymous], 2009, PLOS PATHOG, V5

[5]

Toll-like receptor 2 ligands promote microglial cell death by inducing autophagy [J].

Arroyo, Daniela S. ;

Soria, Javier A. ;

Gaviglio, Emilia A. ;

Garcia-Keller, Constanza ;

Cancela, Liliana M. ;

Rodriguez-Galan, Maria C. ;

Wang, Ji Ming ;

Iribarren, Pablo .

FASEB JOURNAL, 2013, 27 (01) :299-312

[6]

Toll-like receptors are key players in neurodegeneration [J].

Arroyo, Daniela S. ;

Soria, Javier A. ;

Gaviglio, Emilia A. ;

Rodriguez-Galan, Maria C. ;

Iribarren, Pablo .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2011, 11 (10) :1415-1421

[7]

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum [J].

Axe, Elizabeth L. ;

Walker, Simon A. ;

Manifava, Maria ;

Chandra, Priya ;

Roderick, H. Llewelyn ;

Habermann, Anja ;

Griffiths, Gareth ;

Ktistakis, Nicholas T. .

JOURNAL OF CELL BIOLOGY, 2008, 182 (04) :685-701

[8]

Two distinct pathways for targeting proteins from the cytoplasm to the vacuole/lysosome [J].

Baba, M ;

Osumi, M ;

Scott, SV ;

Klionsky, DJ ;

Ohsumi, Y .

JOURNAL OF CELL BIOLOGY, 1997, 139 (07) :1687-1695

[9]

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease [J].

Barrett, Jeffrey C. ;

Hansoul, Sarah ;

Nicolae, Dan L. ;

Cho, Judy H. ;

Duerr, Richard H. ;

Rioux, John D. ;

Brant, Steven R. ;

Silverberg, Mark S. ;

Taylor, Kent D. ;

Barmada, M. Michael ;

Bitton, Alain ;

Dassopoulos, Themistocles ;

Datta, Lisa Wu ;

Green, Todd ;

Griffiths, Anne M. ;

Kistner, Emily O. ;

Murtha, Michael T. ;

Regueiro, Miguel D. ;

Rotter, Jerome I. ;

Schumm, L. Philip ;

Steinhart, A. Hillary ;

Targan, Stephan R. ;

Xavier, Ramnik J. ;

Libioulle, Cecile ;

Sandor, Cynthia ;

Lathrop, Mark ;

Belaiche, Jacques ;

Dewit, Olivier ;

Gut, Ivo ;

Heath, Simon ;

Laukens, Debby ;

Mni, Myriam ;

Rutgeerts, Paul ;

Van Gossum, Andre ;

Zelenika, Diana ;

Franchimont, Denis ;

Hugot, Jean-Pierre ;

de Vos, Martine ;

Vermeire, Severine ;

Louis, Edouard ;

Cardon, Lon R. ;

Anderson, Carl A. ;

Drummond, Hazel ;

Nimmo, Elaine ;

Ahmad, Tariq ;

Prescott, Natalie J. ;

Onnie, Clive M. ;

Fisher, Sheila A. ;

Marchini, Jonathan ;

Ghori, Jilur .

NATURE GENETICS, 2008, 40 (08) :955-962

[10]

Network organization of the human autophagy system [J].

Behrends, Christian ;

Sowa, Mathew E. ;

Gygi, Steven P. ;

Harper, J. Wade .

NATURE, 2010, 466 (7302) :68-U84

← 1 2 3 4 5 6 7 8 9 10 →