Myeloid differentiation (MyD) primary response genes in hematopoiesis

被引：43

作者：

Liebermann, DA

Hoffman, B

机构：

[1] Temple Univ, Sch Med, Fels Inst Canc Res & Mol Biol, Philadelphia, PA 19140 USA

[2] Temple Univ, Sch Med, Dept Biochem, Philadelphia, PA 19140 USA

来源：

ONCOGENE | 2002年 / 21卷 / 21期

关键词：

IRF-1; EGR-1; Jun; MyD88; MyD118; GADD45;

D O I：

10.1038/sj.onc.1205312

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Myeloid Differentiation (MyD) primary response and Growth Arrest DNA-Damage (Gadd) genes comprise a set of overlapping genes, including known (IRF-1, EGR-1, Jun) and novel (MyD88, Gadd45alpha MyD118/ Gadd45beta, GADD45gamma, MyD1161/Gadd34) genes, that have been cloned by virtue of there being co-ordinately induced upon the onset of terminal myeloid differentiation. This review delineates the role MyD genes play in blood cell development, where they function as positive regulators of terminal differentiation, lineage specific blood cell development and control of blood cell homeostasis, including growth inhibition and apoptosis.

引用

页码：3391 / 3402

页数：12

共 175 条

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[2]

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