Physicochemical properties of enrofloxacin

被引：89

作者：

Lizondo, M ^{[1
]}

Pons, M ^{[1
]}

Gallardo, M ^{[1
]}

Estelrich, J ^{[1
]}

机构：

[1] UNIV BARCELONA,FAC FARM,UNITAT FISICOQUIM,E-08028 BARCELONA,CATALONIA,SPAIN

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1997年 / 15卷 / 12期

关键词：

fluoroquinolone; enrofloxacin; solubility; dissociation constants; partition constants; physicochemical properties;

D O I：

10.1016/S0731-7085(96)02033-X

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The physicochemical properties of enrofloxacin, a fluoroquinolone that inhibits the activity of bacterial DNA gyrase, are described. Its spectral, solubility and related physicochemical characteristics are discussed. The dissociation behaviour of enrofloxacin was examined by UV spectrophotometry at 25 degrees C in a series of buffers ranging from pH 1 to 10. The corresponding macro-and microscopic dissociation constants were calculated. The apparent n-octanol-water partition coefficients were measured from pH 2 to 10. (C) 1997 Elsevier Science B.V.

引用

页码：1845 / 1849

页数：5

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