Plasma exchange and heart-liver transplantation in a patient with homozygous familial hypercholesterolemia

被引：25

作者：

Offstad, J ^{[1
]}

Schrumpf, E ^{[1
]}

Geiran, O ^{[1
]}

Soreide, O ^{[1
]}

Simonsen, S ^{[1
]}

机构：

[1] Natl Hosp Norway, Dept Cardiol, Oslo, Norway

来源：

CLINICAL TRANSPLANTATION | 2001年 / 15卷 / 06期

关键词：

familial hypercholesterolemia; heart-liver transplantation; plasma exchange;

D O I：

10.1034/j.1399-0012.2001.150612.x

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

A female patient born in 1950 underwent plasma exchange and concomitant drug therapy for 20 yr due to homozygous familial hypercholesterolemia. Plasma exchange reduced total cholesterol levels from 25-30 mmol/L (967-1160 mg/dL) before treatment to 9.5 mmol/ L (363 mg,/dL) with regression of xanthomas and no side effects of long-term treatment. Due to end-stage calcific left ventricular outflow tract obstruction not amenable to standard valve reconstructive surgery, a combined heart-liver transplantation was successfully performed in 1996. She is without symptoms and living a normal life 4 yr after transplantation. Total cholesterol value is normal (4.7 mmol/ L [182 mg/dL]) using a moderate dose of statins. Selective coronary angiography is without signs of graft vascular disease and the liver function is normal.

引用

页码：432 / 436

页数：5

共 30 条

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