Morphologic phenotyping with MR microscopy: The visible mouse

被引：190

作者：

Johnson, GA ^{[1
]}

Cofer, GP ^{[1
]}

Gewalt, SL ^{[1
]}

Hedlund, LW ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Ctr In Vivo Microscopy, Durham, NC 27710 USA

来源：

RADIOLOGY | 2002年 / 222卷 / 03期

关键词：

animals; magnetic resonance (MR); technology; special reports;

D O I：

10.1148/radiol.2223010531

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A method for rapid morphologic phenotyping is demonstrated by using magnetic resonance microscopy. Whole fixed C57BL/6J mice were imaged at 110-mum isotropic resolution; limited volumes of the intact specimen, at 50-mum isotropic resolution; and isolated organs, at 25-mum isotropic resolution. The three-dimensional imaging technique was applied to uricase knockout mice to demonstrate the method for the evaluation of morphologic phenotype. (C) RSNA, 2002.

引用

页码：789 / 793

页数：5

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