Snythesis of Δ12,14-15-deoxy-PG-J1 methyl ester and epi-Δ12-15-deoxy-PG-J1

被引：34

作者：

Iqbal, M ^{[1
]}

Li, YF ^{[1
]}

Evans, P ^{[1
]}

机构：

[1] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England

来源：

TETRAHEDRON | 2004年 / 60卷 / 11期

关键词：

Delta(12,14)-15-deoxy-PGJ(1); conjugate addition-Peterson olefination; epi-Delta(12)-15-deoxy-PG(1); cross-conjugated cyclopenteone;

D O I：

10.1016/j.tet.2004.01.048

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of racemic Delta(12,14)-15-deoxy-PG-J(1) is readily achieved in six steps employing as the key transformation a one-pot conjugate addition-Peterson olefination sequence using exo-2-trimethylsilyl-3a,4,7,7a-tetrahydro-4,7-methanoinden-1-one. Additionally a Noyori-type three-component coupling approach is employed for the synthesis of enantioenriched epi-Delta(12)-15-deoxy-PG-J(1) from 4(S)-tert-butyldimethylsilyloxycyclopent-2-enone. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2531 / 2538

页数：8

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