Cytochrome p450 2C (CYP2C) in ischemic heart injury and vascular dysfunction

被引：24

作者：

Chehal, MK ^{[1
]}

Granville, DJ ^{[1
]}

机构：

[1] Univ British Columbia, James Hogg iCAPTURE Ctr Cardiovasc & Pulm Res, St Pauls Hosp, Vancouver, BC V6Z 1Y6, Canada

来源：

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 2006年 / 84卷 / 01期

关键词：

cytochrome p450 enzymes; endothelium; vascular dysfunction; myocardial infarction; ischemia; reperfusion; heart attack; atherosclerosis; oxidative stress; reactive oxygen species; superoxide;

D O I：

10.1139/y05-139

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The cytochrome p450 2C (CYP2C) monooxygenase family is a key player in the generation of epoxyeicosairienoic acids. It has recently become apparent that CYP plays an important role in cardiovascular physiology and contributes to the pathogenesis of various cardiovascular diseases. In particular, several Studies have demonstrated it role for these enzymes in cardiac ischemia and reperfusion injury. The current review summarizes the role of the CYP epoxygenase, CYP2C9, in ischemic heart disease and vascular homeostasis.

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页码：15 / 20

页数：6

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