Delayed onset of systemic lupus erythematosus in patients with "full-house" nephropathy

被引:72
作者
Gianviti, A [1 ]
Barsotti, P [1 ]
Barbera, V [1 ]
Faraggiana, T [1 ]
Rizzoni, G [1 ]
机构
[1] Bambino Gesu Childrens Res Hosp, Div Nephrol & Dialysis, I-00165 Rome, Italy
关键词
full-house immunoflourescence; nephropathy; systemic lupus erythematosus; antinuclear antibodies; anti-double-stranded DNA antibodies glomerulonephritis;
D O I
10.1007/s004670050681
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Three patients are described who presented with a glomerulopathy suggestive of lupus nephritis in the absence of other clinical and biological evidence of systemic lupus erythematosus (SLE). Renal biopsies showed a "full-house" immunofluorescence pattern and two patients also had cytoplasmic tubuloreticular inclusions by electron microscopy. All these patients developed antinuclear and anti-double-stranded DNA antibodies 3, 5, and 10 years after their original presentation. Subsequently, 1 patient also developed clinical symptoms of lupus. Reviewing all renal biopsies performed in our department, we found 14 additional patients who presented with a "full-house" immunofluorescence glomerulonephritis in the absence of other features of SLE. After a mean follow-up of 5.8 years, these patients have not developed serological or clinical evidence of SLE. We conclude that a "full-house" glomerulopathy in children may be the first symptom of SLE, especially when cytoplasmic tubuloreticular inclusions are detected. The appearance of other clinical and biological symptoms may be delayed by several years.
引用
收藏
页码:683 / 687
页数:5
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