CD4+CD25+ regulatory T cells and graft-versus-host disease

被引：41

作者：

Hoffmann, P

Edinger, M

机构：

[1] Univ Hosp Regensburg, Dept Hematol & Oncol, D-93053 Regensburg, Germany

[2] Univ Hosp Regensburg, Inst Immunol, D-93053 Regensburg, Germany

来源：

SEMINARS IN HEMATOLOGY | 2006年 / 43卷 / 01期

关键词：

D O I：

10.1053/j.seminhematol.2005.09.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Peripheral suppression of autoreactive T cells by specialized T-cell populations is one of several mechanisms ensuring self-tolerance within the adaptive immune system. Thymus-derived CD4+CD25+ T cells expressing the transcriptional repressor FOXP3 mediate such immunoregulatory functions and are pivotal for the prevention of autoimmunity. As peripheral tolerance induction is a prerequisite for successful treatment outcome after allogeneic hematopoietic stem cell transplantation (HSCT), the role of CD4 +CD25+ T cells in transplantation models and clinical trials is now under investigation in many laboratories. Here we summarize recent results regarding protection from graft-versus-host disease (GVHD) by adoptively transferred CD4+CD25+ T cells in mice and discuss early findings from clinical studies in HSCT. © 2006 Elsevier Inc. All rights reserved.

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页码：62 / 69

页数：8

相关论文

共 79 条

[1] Modeling the impact of organizational change: A Bayesian network approach [J].

Anderson, RD ;

Lenz, RT .

ORGANIZATIONAL RESEARCH METHODS, 2001, 4 (02) :112-130

[2] Regulatory CD4 T cells control the size of the peripheral activated/memory CD4 T cell compartment [J].

Annacker, O ;

Burlen-Defranoux, O ;

Pimenta-Araujo, R ;

Cumano, A ;

Bandeira, A .

JOURNAL OF IMMUNOLOGY, 2000, 164 (07) :3573-3580

[3] Phenotype, localization, and mechanism of suppression of CD4+CD25+ human thymocytes [J].

Annunziato, F ;

Cosmi, L ;

Liotta, F ;

Lazzeri, E ;

Manetti, R ;

Vanini, V ;

Romagnani, P ;

Maggi, E ;

Romagnani, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (03) :379-387

[4] Human CD4+CD25+ regulatory T cells [J].

Baecher-Allan, C ;

Viglietta, V ;

Hafler, DA .

SEMINARS IN IMMUNOLOGY, 2004, 16 (02) :89-97

[5] Natural regulatory T cells in infectious disease [J].

Belkaid, Y ;

Rouse, BT .

NATURE IMMUNOLOGY, 2005, 6 (04) :353-360

[6] Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4+25+ immunoregulatory T cells [J].

Bensinger, SJ ;

Bandeira, A ;

Jordan, MS ;

Caton, AJ ;

Laufer, TM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (04) :427-438

[7] Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells [J].

Bensinger, SJ ;

Walsh, PT ;

Zhang, JD ;

Carroll, M ;

Parsons, R ;

Rathmell, JC ;

Thompson, CB ;

Burchill, MA ;

Farrar, MA ;

Turka, LA .

JOURNAL OF IMMUNOLOGY, 2004, 172 (09) :5287-5296

[8] Foxp3 interacts with nuclear factor of activated T cells and NF-κB to repress cytokine gene expression and effector functions of T helper cells [J].

Bettelli, E ;

Dastrange, M ;

Oukka, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (14) :5138-5143

[9] Suppressive properties of human CD4+CD25+ regulatory T cells are dependent on CTLA-4 expression [J].

Birebent, B ;

Lorho, R ;

Lechartier, H ;

de Guibert, S ;

Alizadeh, M ;

Vu, N ;

Beauplet, A ;

Robillard, N ;

Semana, G .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2004, 34 (12) :3485-3496

[10] Neuropilin-1: a surface marker of regulatory T cells [J].

Bruder, D ;

Probst-Kepper, M ;

Westendorf, AM ;

Geffers, R ;

Beissert, S ;

Loser, K ;

von Boehmer, H ;

Buer, J ;

Hansen, W .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2004, 34 (03) :623-630

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