Antitumoral effects of squamocin on parental and multidrug resistant MCF7 (human breast adenocarcinoma) cell lines

被引：33

作者：

Raynaud, S

Némati, F

Miccoli, L

Michel, P

Poupon, MF

Fourneau, C

Laurens, A

Hocquemiller, R ^{[1
]}

机构：

[1] Univ Paris 11, Fac Pharm, URA CNRS 1843 BIOCIS, Lab Pharmacognosie, F-92296 Chatenay Malabry, France

[2] Inst Curie, CNRS, UMR 147, Sect Rech,Lab Cytogenet Mol & Oncol, F-75248 Paris 05, France

来源：

LIFE SCIENCES | 1999年 / 65卷 / 05期

关键词：

squamocin; MCF7 cell lines; multidrug resistance; antiproliferative activity; cell cycle alterations;

D O I：

10.1016/S0024-3205(99)00273-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The antiproliferative effects of squamocin, one of the easiest annonaceous acetogenins to obtain, were studied in the parental (MCF7-S) and the multidrug resistant (MCF7-R) human breast adenocarcinoma cell lines. Squamocin inhibited proliferation of both cell lines identically, by blocking the cell cycle in the G1-phase. This inhibition was reversible in the long term. Squamocin decreased the ATP pool in both MCF7 cell lines, but did not seem to induce apoptosis. Cytotoxic activity of adriamycin was not restored in MCF7-R Pgp expressing cells by squamocin addition.

引用

页码：525 / 533

页数：9

共 21 条

[1] MODE OF ACTION OF BULLATACIN - A POTENT ANTITUMOR AND PESTICIDAL ANNONACEOUS ACETOGENIN [J].