MEKKs, GCKs, MLKs, PAKs, TAKs, and Tpls: Upstream regulators of the c-Jun amino-terminal kinases?

被引：298

作者：

Fanger, GR ^{[1
]}

Gerwins, P ^{[1
]}

Widmann, C ^{[1
]}

Jarpe, MB ^{[1
]}

Johnson, GL ^{[1
]}

机构：

[1] NATL JEWISH CTR IMMUNOL & RESP MED, DIV BASIC SCI, PROGRAM MOL SIGNAL TRANSDUCT, DENVER, CO 80206 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1997年 / 7卷 / 01期

关键词：

D O I：

10.1016/S0959-437X(97)80111-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Regulation of the mitogen-activated protein kinase (MAPK) family members - which include the extracellular response kinases (ERKs), p38/HOG1, and the c-Jun amino-terminal kinases (JNKs)- plays a central role in mediating the effects of diverse stimuli encompassing cytokines, hormones, growth factors and stresses such as osmotic imbalance, heat shock, inhibition of protein synthesis and irradiation. A rapidly increasing number of kinases that activate the JNK pathways has been described recently, including the MAPK/ERK kinase kinases, p21-activated kinases, germinal center kinase, mixed lineage kinases, tumor progression locus 2, and TGF-beta-activated kinase. Thus, regulation of the JNK pathway provides an interesting example of how many different stimuli can converge into regulating pathways critical for the determination of cell fate.

引用

页码：67 / 74

页数：8

共 58 条

[1] Molecular cloning of mitogen-activated protein ERK kinase kinases (MEKK) 2 and 3 - Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase [J].