Loss of the phospholipase C gene product induces massive endocytosis of rhodopsin and arrestin in Drosophila photoreceptors

被引：34

作者：

Orem, NR ^{[1
]}

Dolph, PJ ^{[1
]}

机构：

[1] Dartmouth Coll, Dept Biol Sci, Hanover, NH 03755 USA

来源：

VISION RESEARCH | 2002年 / 42卷 / 04期

关键词：

rhodopsin; arrestin; retinitis pigmentosa; apoptosis;

D O I：

10.1016/S0042-6989(01)00229-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previously we have shown that a subset of visual transduction mutants in Drosophila melanogaster induce the formation of stable complexes between rhodopsin and arrestin. One such mutant is in a visual system-specific phospholipase C (PLC). The rhodopsin/arrestin complexes generated in PLC mutants induce massive retinal degeneration. Here we demonstrate that both arrestin and rhodopsin undergo light-dependent endocytosis in a PLC mutant background. Interestingly, the internalized rhodopsin is rapidly degraded, but the arrestin is fully stable. The data are discussed with respect to mechanisms of arrestin-mediated endocytosis and human retinal disease. (C) 2002 Elsevier Science Ltd, All rights reserved.

引用

页码：497 / 505

页数：9

共 48 条

[1] The formation of stable rhodopsin-arrestin complexes induces apoptosis and photoreceptor cell degeneration [J].